Journal of International Psychiatry

[Abstract] Objective: To study the effects of dexmedetomidine and ketamine anesthesia on intraocular pressure (IOP) and depression score in patients with depression. Methods: 300 patients with depression were selected from February 2017 to December 2018. They were divided into control group and observation group, 150 cases in each group. The patients in both groups were treated with MECT. Ketamine was used in the control group and dexmedetomidine was used in the observation group. The intraocular pressure, depression score, serum markers before and after treatment and complications were compared between the two groups. Results: (1) at t0 and T2, there was no significant surprise in intraocular pressure (P > 0.05) zero point zero five ）At T1, the intraocular pressure level in the observation group was slightly higher than that in the control group, with statistical significance (P< zero point zero five ）。 (2) At T2, the comprehensive score of depression in the observation group was significantly lower than that in the control group (P< zero point zero five ）。 (3) After treatment, the levels of IL-2 and IL-6 in the observation group were lower than those in the control group, and there was significant difference between the two groups (P< zero point zero five ）。 (4) The results showed that there were 4 complications in the observation group and 14 in the control group. The incidence of complications in the observation group was lower than that in the control group (P< zero point zero five ）。 Conclusion: compared with ketamine, dexmedetomidine plays a more significant role in the treatment of non convulsive electroconvulsive in patients with depression. It is helpful to relieve depression, improve serum markers, and have fewer complications. However, we need to pay attention to the effect on intraocular pressure.

[Key words] depression; electroconvulsive therapy; dexmedetomidine; ketamine; anesthesia; intraocular pressure; depression score reduction