Journal of International Psychiatry

Antipsychotics, as the most important way to treat schizophrenia, are considered to increase the risk of cardiovascular events. However, the impact of antipsychotics on vascular endothelial function, a prognostic indicator of cardiovascular disease, has been rarely reported. According to the current evidence, some antipsychotics can damage the structure and function of vascular endothelial cells by increasing inflammation, oxidative stress, destroying barrier and transmembrane transport, affecting mitochondrial bioenergy and promoting coagulation. In general, most of the current evidence shows that antipsychotics have adverse effects on endothelial cells, but the evidence are still limited.

Antipsychotics; Vascular endothelial cells; Cardiovascular disease; Inflammation; Oxidative stress; Vascular endothelial barrier; Mitochondria; Endothelial growth factor; Antiphospholipid syndrome