Journal of International Psychiatry

[Abstract] Objective To analyze the effect of fluoxetine combined with mosapride on patients after colorectal cancer surgery and its influence on gastrointestinal function and anxiety and depression. Methods Random number table method was used to group 300 patients with colorectal cancer after operation in our hospital. Both groups were given psychological intervention. 150 patients in the control group were treated with mosapride orally, and 150 patients in the observation group were added fluoride on the basis of the control group. Combined treatment with cetin, comparing the number of bowel sounds, anal exhaust time, defecation time, gastrointestinal hormone levels, anxiety and depression mood changes of the two groups of patients before and after treatment, and compared the treatment effect and safety. Results The anal exhaust time, defecation time, SS level, HAMD and HAMA scores of the observation group were lower than those of the control group, MTL level, number of bowel sounds after 5 days, and total effective rate were higher than those of the control group (P<0.05). The incidence of adverse reactions during medication was not statistically significant (P>0.05). Conclusion Fluoxetine combined with mosapride can effectively relieve the anxiety and depression of patients undergoing colorectal cancer surgery, and promote the recovery of gastrointestinal function with high safety.

[Keywords] fluoxetine; mosapride; colorectal cancer; postoperative; anxiety and depression; gastrointestinal function