帕罗西汀应用于骨折术后患者的效果及对疼痛介质与不良心理状态的影响
The effect of paroxetine applied to patients after fracture operation and its influence on pain mediator and unhealthy mental state
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2020, 47(5) |
| 作者 |
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| 作者单位 |
河南省郑州市中原区桐柏北路16号郑州大学附属郑州中心医院骨科一病区 ;
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| 摘要 |
【摘要】 观察骨折术后患者给予帕罗西汀治疗后患者疼痛介质水平及焦虑抑郁情绪变化。方法 将我院97例骨折术后患者采用随机平行对照法进行分组，对照组48例术后给予放松训练结合心理干预，观察组49例在对照组基础上增加帕罗西汀联合治疗，对比两组患者治疗后疼痛介质水平、疼痛评分及焦虑抑郁情绪的变化。结果 观察组5-HT、NO、PGE2水平及SDS、SAS、VAS评分低于对照组（P<0.05）。结论 帕罗西汀能够有效降低股骨粗隆间骨折术后患者疼痛递质水平，减轻疼痛，缓解患者焦虑抑郁情绪。
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| Abstract |
[Abstract] Objective To observe the changes of pain mediator level and anxiety and depression mood of patients after fracture treatment with paroxetine. Methods A total of 97 patients with fractures in our hospital were randomly divided into groups. 48 patients in the control group were given postoperative relaxation training combined with psychological intervention. 49 patients in the observation group added paroxetine combination therapy on the basis of the control group. Changes of pain medium level, pain score and anxiety and depression after treatment. Results The levels of 5-HT, NO, PGE2 and SDS, SAS, VAS in the observation group were lower than those in the control group (P<0.05). Conclusion Paroxetine can effectively reduce the level of pain transmitters in patients with intertrochanteric fractures, relieve pain, and relieve patients anxiety and depre
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| 关键词 |
【关键词】帕罗西汀；骨折；术后；疼痛介质；不良心理状态
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| KeyWord |
[Keywords] paroxetine; fracture; postoperative; pain medium; unhealthy mental state
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| 基金项目 |
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| 页码 |
1025-1027 |
张可方*.
帕罗西汀应用于骨折术后患者的效果及对疼痛介质与不良心理状态的影响 [J].
国际精神病学杂志.
2020; 47; (5).
1025 - 1027.