| Abstract |
【Abstract】Objective: To explore the effect of Simotang oral liquid combined with citalopram in the treatment of patients with irritable bowel syndrome (IBS) accompanied by anxiety, depression and mood and its effect on serum serotonin (5-HT) and norepinephrine (NE), the impact of broken peroxidase (MPO). Methods: A total of 118 patients with IBS with anxiety, depression, and diarrhea who were admitted to our hospital from January 2017 to June 2019 were selected as the research subjects. They were divided into a random number table into a control group and an observation group, 59 cases, both groups. Saccharomyces boulardii was treated, and the control group was given citalopram. The observation group was treated with Simotang oral liquid on the basis of the control group for 1 month. The Hamilton Depression Scale (HAMD) was compared between the two groups before and after treatment Score, Hamilton Anxiety Scale (HAMA) score, gastrointestinal clinical symptoms score, serum 5-HT, NE, MPO level changes and clinical efficacy. Results: There was no significant difference in HAMD and HAMA scores between the two groups of patients before treatment (P>0.05); the HAMD and HAMA scores of the observation group after treatment were significantly lower than those of the control group (P<0.05); serum 5-HT of the two groups of patients before treatment , NE and MPO levels were not statistically significant (P>0.05); serum MPO levels in the observation group after treatment were lower than the control group (P<0.05), 5-HT and NE levels were higher than the control group (P<0.05); two Before treatment, the scores of diarrhea, abdominal pain, urgency, and bloating were not statistically significant (P>0.05); the scores of diarrhea, abdominal pain, urgency, and bloating in the observation group were lower than those in the control group (P<0.05); The post-clinical efficacy was significantly better than the control group (P<0.05). Conclusion: Simotang oral liquid combined with citalopram is effective in treating IBS patients with anxiety and depression and diarrhea. It can effectively adjust serum 5-HT, NE, MPO levels, improve patients depression and anxiety symptoms, and further improve patients diarrhea IBS clinical symptoms, improve clinical efficacy.
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