Journal of International Psychiatry

[Abstract] Objective: To compare and analyze the clinical effect of fluoxetine alone and fluoxetine + high frequency repetitive transcranial magnetic stimulation (hftms) on post cerebral infarction depression. Methods: 162 patients with depression after cerebral infarction in our hospital from May 2019 to may 2020 were selected as the observation objects. According to the principle of double-blind randomized control, the patients were divided into two groups: one group was treated with fluoxetine alone, the other group was called study group (fluoxetine + high frequency repetitive transcranial magnetic stimulation). There were 81 cases in each group. Results: the HAMD depression score of the study group was lower than that of the conventional group (P < 0.05); the ADL score of the study group was higher than that of the conventional group (P < 0.05); the overall efficacy of the study group was higher than that of the conventional group (P < 0.05); there was no difference in adverse reactions between the study group and the conventional group (P > 0.05). Conclusion: the combination of fluoxetine and high frequency repetitive transcranial magnetic stimulation in the treatment of post cerebral infarction depression patients has higher clinical efficacy, can significantly reduce the depression of patients, improve their quality of life, and fewer adverse reactions, safe and reliable, worthy of wide clinical popularization.

[Key words] fluoxetine; high frequency repetitive transcranial magnetic stimulation; cerebral infarction; depression; clinical efficacy