舍曲林联合维生素D治疗COPD合并焦虑抑郁的疗效研究
Clinical Effect of Sertraline Combined with Vitamin D in the Treatment of COPD Patients with Anxiety and Depression
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2020, 47(6) |
| 作者 |
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| 作者单位 |
南阳市中心医院 ;
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| 摘要 |
【摘要】探讨舍曲林联合维生素D辅助治疗慢性阻塞性肺疾病（COPD）合并焦虑抑郁患者的临床疗效。方法 本研究对象为2018年3月~2020年3月106例COPD合并焦虑抑郁患者，数字表法随机均分为两组，对照组进行常规治疗，观察组在常规治疗基础上给予舍曲林联合维生素D治疗。比较两组患者护理前后焦虑自评量表（SAS）、匹兹堡睡眠质量指数(PSQI)、抑郁自评量表（SDS）、1s用力呼气量（FEV1）、COPD 评估测试(CAT)量表以及6分钟步行距离（6MWT）。结果 治疗后两组SAS评分、SDS评分、PSQI指数均显著降低，治疗后观察组显著低于对照组，（P<0.05）；治疗后两组FEV1、CAT评分、6MWT均显著升高，治疗后观察组CAT评分、6MWT显著低于对照组，（P<0.05），FEV1差异无统计学意义（P>0.05）。结论 舍曲林联合维生素D辅助治疗COPD合并焦虑抑郁能显著改善不良情绪、提升睡眠治疗，虽对肺功能无显著影响，但能提高患者的活动能力及生活质量。
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| Abstract |
[Abstract] Objective To explore the clinical efficacy of sertraline combined with vitamin D in the treatment of patients with chronic obstructive pulmonary disease (COPD), anxiety and depression. Methods A total of 106 patients with COPD, anxiety and depression from March 2018 to March 2020 were the subjects of this study. They were randomly divided into two groups by the digital table method. The control group was given conventional treatment, and the observation group was given Sertraline combined with vitamin D on the basis of conventional treatment. Self-rating anxiety scale (SAS), Pittsburgh sleep quality index (PSQI), depression self-rating scale (SDS), 1s forced expiratory volume (FEV1), COPD assessment test (CAT) scale and 6 minutes walking distance (6MWT) were compared between the two groups of patients before and after nursing. Results After treatment, the SAS score, SDS score, and PSQI index of the two groups were significantly reduced, and the observation group was significantly lower than the control group after treatment (P<0.05). After treatment, the FEV1, CAT score and 6MWT of the two groups were significantly increased. After treatment, the CAT score and 6MWT of the observation group were significantly lower than that of the control group (P<0.05). There was no statistically significant difference in FEV1 (P>0.05). Conclusion Sertraline combined with vitamin D in the treatment of COPD combined with anxiety and depression can significantly improve bad mood and improve sleep therapy. Although it has no significant effect on lung function, it can improve the patients activity ability and quality of life.
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| 关键词 |
关键词：舍曲林；维生素D；慢性阻塞性肺疾病；焦虑抑郁
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| KeyWord |
Key words Sertraline；Vitamin D; Chronic Obstructive Pulmonary Disease; Anxiety and Depression
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| 基金项目 |
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| 页码 |
1184-1186 |
郭娜*.
舍曲林联合维生素D治疗COPD合并焦虑抑郁的疗效研究 [J].
国际精神病学杂志.
2020; 47; (6).
1184 - 1186.