International Journal of Clinical Research

Unexpected ovarian hyporesponsiveness is one of the important challenges faced in the field of assisted reproduction. This article explores the influencing factors of patients with unexpected ovarian hyporesponsiveness and the new progress in personalized treatment research. In terms of influencing factors, patient factors, iatrogenic factors, and other factors may all lead to the occurrence of unexpected ovarian hyporesponsiveness. Aging is closely related to the decline of ovarian reserve function, and genetic variation and polymorphism also play a role in it; The damage to ovarian tissue caused by ovarian surgery, chemotherapy, and radiotherapy cannot be ignored, while psychological stress and environmental pollution may also have potential impacts on ovarian function. In terms of individualized treatment, patients are accurately evaluated and predicted through ovarian reserve function assessment indicators and prediction models before treatment. Individualized ovulation induction programs are constantly being optimized, traditional programs are adjusted according to patient conditions, and new ovulation induction drugs and technologies are gradually being applied.

Unexpected ovarian hyporesponsiveness; Influencing factors; Individualized treatment; Progress