International Journal of Clinical Research

Objective To analyze the structural characteristics of intestinal flora in patients with colorectal polyps, and to understand the characteristics of intestinal flora in patients with colorectal polyps. Methods Stool samples of patients with large intestine polyps meeting the ataxic standard and healthy physical examination subjects were collected from September 2022 to December 2023 in the Second Affiliated Hospital of Dali University, and the intestinal flora sequencing data were analyzed by 16SrDNA gene sequencing method. Results Compared with the healthy control group, the diversity and abundance of intestinal flora decreased in both primary and recurrent intestinal polyps. At the phylum level, the relative abundance of Proteobacteria increased in the initial and recurrent groups, while the relative abundance of Bacteroidetes decreased. At the genus level, the relative abundences of Escherichia coli Shigella, Streptococcus and Rumen cocci increased in the initial and recurrent groups, while the relative abundences of Praxobacter and Agarose decreased. Enterococcus, streptococcus, actinomyces, Rombuzia and Parasutterella were dominant groups in the recurrence group. Conclusion The diversity and abundance of intestinal flora decreased significantly in patients with recurrent intestinal polyps, and Enterococcus, actinomyces and Rombuzia were the dominant flora, which is of great significance for the prevention of recurrence of colorectal polyps.

Large intestine polyp; Intestinal flora; 16SrDNA sequencing method; Recurrent intestinal polyps; Bacteroidota