International Journal of Clinical Research

Objective This study aims to observe the immune effect of children after receiving hepatitis B vaccine. Methods Using a prospective cohort study design, 80 children managed from January 2022 to December 2.2023 were randomly divided into observation group and control group, with 40 cases in each group. The observation group received three-dose hepatitis B vaccination with personalized care; the control group received three-dose hepatitis B vaccination only. The main observation measures of the study included antibody titer, incidence of adverse reactions, immune success rate, and immune persistence. Results The antibody titer of children in the observation group was higher than that of the control group (P <0.05), the incidence of adverse reactions was lower than that in the control group (P <0.05), and the immune success rate and immune persistence were better than that of the control group. Conclusion The three doses of hepatitis B vaccine with personalized nursing can effectively improve the immune effect of children after hepatitis B vaccine.

Hepatitis B vaccine; Children vaccination; Immune effect; Antibody titers; Personalized care