International Journal of Clinical Research

Objective Observation and analysis of the clinical efficacy and application value of synchronous radiotherapy and chemotherapy combined with early comprehensive nutritional therapy in patients with locally advanced nasopharyngeal carcinoma. Methods Sixty patients with locally advanced nasopharyngeal carcinoma who received medical treatment in the hospital were selected (sample included: 60 cases; sample included time: May 2023 to May 2024), and were randomly divided into control and experimental groups based on random numbers. The number of observed cases was highly consistent. Implement synchronous radiotherapy and chemotherapy separately, and combine synchronous radiotherapy and chemotherapy with early comprehensive nutritional therapy. Collect and analyze treatment effects. Results Compared with the control group (synchronous radiotherapy and chemotherapy), the experimental group (synchronous radiotherapy and chemotherapy combined with early comprehensive nutritional therapy) had higher levels of albumin, transferrin, hemoglobin, CD3+, CD4+, CD8+* CD28+, CD4+/CD8+, and higher quality of life scores (role function/emotional function/cognitive function/social function/physical function/overall health), with statistically significant differences (P<0.05). Conclusion Simultaneous chemoradiotherapy combined with early comprehensive nutritional therapy can effectively reduce the adverse effects of disease and treatment on the nutritional status of locally advanced nasopharyngeal carcinoma patients, promote the improvement of immune status, enhance quality of life, improve prognosis, and have high application value.

Localized advanced nasopharyngeal carcinoma; Synchronous radiotherapy and chemotherapy; Early comprehensive nutritional therapy; Treatment effect