CRY2基因单核苷酸多态性与肝细胞肝癌预后分析

Analysis of single nucleotide polymorphisms of CRY2 gene and prognosis of hepatocellular carcinoma

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DOI 10.12208/j.ijcr.20250179
刊名
International Journal of Clinical Research
年,卷(期) 2025, 9(4)
作者
作者单位

安徽医科大学附属省立医院 安徽合肥

摘要
目的 分析生物节律基因单核昔酸多态性(SNPs)与肝癌患者预后相关性。方法 选取2021年7月-2023年7月接受治疗的原发性肝细胞癌患者137例,应用SeGuenomiPLEX分型技术对所有患者进行基因分型,记录并分CRYZ基因单核昔酸多态性与肝癌患者临床治疗预后间的关联性。结果 研究对CRYZ:rsZZ9Z910进行了分层分析发现,该位点基因型与年龄超过52岁基肿瘤<5cm患者的预后密切相关。结论 CRYZ基因单核昔酸多态性有望成为一种独立的预后指标,用肝细胞肝癌患者临床治疗后的预后评价。
Abstract
Objective To analyze the correlation between biorhythm gene mononucleic acid polymorphisms (SNPs) and prognosis of patients with liver cancer. Methods A total of 137 patients with primary hepatocellular carcinoma who received treatment from July 2021 to July 2023 were selected. SeGuenomiPLEX typing technique was used to genotype all patients, and the association between mononucleic acid polymorphism of CRYZ gene and clinical treatment prognosis of patients with hepatocellular carcinoma was recorded and separated. Results Stratified analysis of CRYZ:rsZZ9Z910 showed that this genotype was closely related to the prognosis of patients older than 52 years with basal tumors < 5cm. Conclusion CRYZ gene mononucleic acid polymorphism is expected to be an independent prognostic indicator for patients with hepatocellular carcinoma after clinical treatment.
关键词
肝脏;单核昔酸多态性;肝细胞肝癌;预后;生物节律基因
KeyWord
Liver; Monocycloxylic acid polymorphism; Hepatocellular carcinoma; Prognosis; Biological rhythm gene
基金项目
页码 33-36
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魏明童,荚卫东*. CRY2基因单核苷酸多态性与肝细胞肝癌预后分析 [J]. 国际临床研究杂志. 2025; 9; (4). 33 - 36.

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