溃疡性结肠炎的治疗研究进展-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

溃疡性结肠炎的治疗研究进展

Advances in the treatment research of ulcerative colitis

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DOI	10.12208/j.ijcr.20250203
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2025, 9(4)
作者	邓翠¹,郑盛²*,杨涓²,
作者单位	1 大理大学临床医学院云南大理,2 大理大学第二附属医院云南昆明
摘要	溃疡性结肠炎（ulcerative colitis, UC）是一种慢性炎症性肠病，现有治疗包括5氨基水杨酸、糖皮质激素、生物制剂等。近年研究显示，新型生物制剂（如抗TL1A药物PF06480605）在II期试验中实现临床缓解率65%；间充质干细胞（MSC）联合人参皂苷Rg1显著降低炎症因子（IL6下降40%）；粪便微生物移植（FMT）可使50%难治性UC患者达到内镜缓解。本文综述指出，糖皮质激素通过纳米递送系统（如SAPEIDDS）可减少全身副作用（肝毒性降低30%），而乌司奴单抗（Ustekinumab）在难治性UC中维持4年疗效。尽管治疗手段多样，UC仍面临易复发、费用高等挑战，未来需探索基因编辑与AI驱动的精准医疗。
Abstract	Ulcerative colitis (ulcerative colitis, UC) is a chronic inflammatory bowel disease. existing treatments include 5 aminosalicylic acid, glucocorticoids, biological agents, etc. Recent studies have shown that novel biologics (e. g., anti-TL 1 A drug PF06480605) achieved clinical remission rates of 65% in phase II trials; mesenchymal stem cells (MSC) combined with ginsenoside Rg 1 significantly reduced inflammatory factors (40% decrease in IL 6); and fecal microbial transplantation (FMT) achieved endoscopic remission in 50% of patients with refractory UC disease. This review showed that corticosteroids reduced systemic side effects through nanodelivery systems (e. g., SAPEIDDS) (30% reduction in hepatotoxicity), while uinumab (Ustekinumab) was maintained in refractory UC for 4 years. Despite the variety of treatments, UC still faces the challenges of easy recurrence and high cost. In the future, gene editing and AI-driven precision medicine should be explored.
关键词	溃疡性结肠炎；生物制剂；间充质干细胞；肠道菌群；精准医疗
KeyWord	Ulcerative colitis; Biologics; Mesenchymal stem cells (MSCs); Gut microbiota; Precision medicine
基金项目
页码	126-131

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邓翠,郑盛*,杨涓. 溃疡性结肠炎的治疗研究进展 [J]. 国际临床研究杂志. 2025; 9; (4). 126 - 131.

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