International Journal of Clinical Research

Objective To observe the effect of the traditional Chinese medicine Xiaobi Xunxi Formula combined with moxibustion in the treatment of type 2 diabetic peripheral neuropathy. Methods A randomized controlled clinical trial was conducted. The subjects of the trial were type 2 diabetic patients with peripheral neuropathy. A total of 60 trial samples were included, and the sample selection period was from June 2023 to June 2024. After random grouping of the samples, different treatments were implemented and they were divided into the control group (n=30) and the observation group (n=30). The control group was treated with conventional Western medicine (mecobalamin) for 2 months. The observation group was treated jointly with the Xiaobi Xunxi Formula and Zusanli moxibustion method, and the treatment period was 2 months. Before the treatment, the severity of clinical symptoms and signs in the two groups was evaluated. The therapeutic effect was evaluated two months after the treatment, and the severity of clinical symptoms and signs was evaluated again. Safety observations were carried out, and the occurrence of adverse reactions during the implementation of the two groups of different treatment regimens was statistically analyzed. Results Before treatment, the severity of clinical symptoms and signs in both groups was evaluated. The scoring results were compared and tested. The score of the control group was higher than that of the observation group, but the difference was not significant (P > 0.05). The therapeutic effect was evaluated after 2 months of treatment. The total effective rate of the control group was 73.33%, which was significantly lower than that of the observation group (93.33%) (P<0.05). Two months after the treatment, the severity of clinical symptoms and signs was evaluated again. The differences between the groups were compared and evaluated. The control group was higher than the observation group, and the difference was significant (P<0.05). After 2 months of treatment, compared with the severity score results of clinical symptoms and signs before treatment within the group, the scores of both groups decreased significantly (P<0.05). No serious adverse reactions occurred in either group. In the observation group, 3 cases had slight redness and swelling of the local skin after fumigation and washing, which relieved spontaneously. Conclusion The Xiaobi Xunxi formula combined with moxibustion can effectively improve the symptoms and signs of patients with DPN, and has good safety.

Diabetic peripheral neuropathy; Qi deficiency and blood stasis type; Xiao Bi Fang; Moxibustion; Combination of traditional Chinese and Western medicine