International Journal of Clinical Research

Objective To explore the clinical significance of peripheral blood Urinary Microalbuminuria(MALB) and D-dimer in children with anaphylactoid purpura. Methods We conducted a retrospective analysis of pediatric HSP patients admitted to our hospital, measuring serum D-dimer and urinary microalbuminuria (MALB) levels. Logistic regression was used to identify risk factors for renal impairment, while ROC curve analysis evaluated the diagnostic performance of these biomarkers. Results Urinary microalbuminuria(MALB) demonstrated an AUC of 0.886 with 84.0% sensitivity and 78.7% specificity. D-dimer showed an AUC of 0.756 (70.5% sensitivity, 79.2% specificity). Combined detection achieved superior diagnostic accuracy (AUC=0.890), significantly outperforming either marker alone (p<0.05). Conclusion As non-invasive biomarkers, both urinary MALB and serum D-dimer have significant clinical value for early identification of renal involvement in HSP. Their combined use enhances diagnostic efficacy and may potentially reduce the need for invasive renal biopsies in selected cases.

Children allergic purpura; Renal damage; Urinary microalbuminuria blood; D – dimer