癌相关成纤维细胞源性细胞外囊泡携带IGF-1对口腔鳞状细胞癌细胞增殖的影响
The effect of IGF-1 carried by extracellular vesicles derived from cancer-associated fibroblasts on the proliferation of oral squamous cell carcinoma cells
ES评分 0
| DOI |
10.12208/j.ijcr.20250281 |
| 刊名 |
International Journal of Clinical Research
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| 年，卷(期) |
2025, 9(6) |
| 作者 |
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| 作者单位 |
广西医科大学 广西南宁
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| 摘要 |
口腔鳞癌（OSCC）进展受肿瘤微环境中CAFs调控，但其通过sEVs影响OSCC的机制不明。本研究发现CAFs高表达IGF-1（较正常成纤维细胞高3.2倍），其sEVs可被OSCC细胞摄取，促进增殖（1.8倍）和克隆形成（2.3倍）。机制上，CAFs-sEVs通过IGF-1激活AKT/ERK通路，敲减IGF-1使促增殖效应降低65%。临床证实CAFs密度与不良预后相关。该研究首次揭示CAFs通过sEVs-IGF-1轴驱动OSCC进展，为靶向治疗提供新靶点。
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| Abstract |
The progression of oral squamous cell carcinoma (OSCC) is regulated by CAFs in the tumor microenvironment, but the mechanism by which it affects OSCC through sEVs is unclear. This study found that CAFs highly expressed IGF-1 (3.2 times higher than normal fibroblasts), and their sEVs could be taken up by OSCC cells, promoting proliferation (1.8 times) and clone formation (2.3 times). Mechanistically, CAFs-sEVs activate the AKT/ERK pathway through IGF-1, and knockdown of IGF-1 reduces the proliferative effect by 65%. Clinically confirmed, the density of CAFs is associated with a poor prognosis. This study reveals for the first time that CAFs drive the progression of OSCC through the sEVs-IGF-1 axis, providing a new target for targeted therapy.
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| 关键词 |
癌相关成纤维细胞；胰岛素样生长因子；口腔鳞状细胞癌
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| KeyWord |
Cancer-associated fibroblasts; Insulin-like growth factor-1; Oral squamous cell carcinoma
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| 基金项目 |
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| 页码 |
54-56 |
陈子豪*.
癌相关成纤维细胞源性细胞外囊泡携带IGF-1对口腔鳞状细胞癌细胞增殖的影响 [J].
国际临床研究杂志.
2025; 9; (6).
54 - 56.