牙源性干细胞外泌体调控牙髓再生的作用机制研究进展-国际临床研究杂志-CSCIED科技核心评价数据库-手机版

牙源性干细胞外泌体调控牙髓再生的作用机制研究进展

Advances in the regulatory mechanisms of dental-derived stem cell exosomes in pulp regeneration

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DOI	10.12208/j.ijcr.20250289
刊名	国际临床研究杂志 International Journal of Clinical Research
年，卷(期)	2025, 9(6)
作者	陈跃敏*,
作者单位	福建医科大学附属口腔医院福建福州
摘要	近年来，牙源性干细胞分泌的外泌体因其旁分泌调控作用成为研究热点。外泌体通过促进干细胞的增殖和迁移，诱导成牙本质细胞分化、血管网络重建及神经功能恢复，从而恢复牙髓生理功能。外泌体具有低免疫原性、无伦理争议及易储存等优势，但其临床应用仍面临分离技术标准化、最佳递送浓度及来源优化等挑战。因此，迫切需要对这些影响因素进行标准化和优化，以确保外泌体作为牙髓再生工具的最佳治疗效果，为口腔疾病治疗提供新策略。
Abstract	In recent years, exosomes secreted by dental-origin stem cells have become a research hotspot due to their paracrine regulatory functions. Exosomes promote the differentiation of odontoblasts, reconstruction of vascular networks, and restoration of neural functions, thereby restoring the physiological functions of dental pulp. Exosomes have advantages such as low immunogenicity, no ethical controversies, and ease of storage. However, their clinical application still faces challenges such as standardization of isolation techniques, optimization of delivery concentrations, and source optimization. Therefore, it is urgent to standardize and optimize these influencing factors to ensure the best therapeutic effect of exosomes as tools for dental pulp regeneration, providing new strategies for the treatment of oral diseases.
关键词	牙源性干细胞；外泌体；牙髓再生
KeyWord	Dental-derived stem cells; Exosomes; Pulp regeneration
基金项目
页码	80-83

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引用本文

陈跃敏*. 牙源性干细胞外泌体调控牙髓再生的作用机制研究进展 [J]. 国际临床研究杂志. 2025; 9; (6). 80 - 83.

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