Journal of International Psychiatry

[Abstract] Objective To analyze the changes of oxidative stress and the changes of postoperative cognitive function in elderly patients undergoing radical resection of lung cancer after maintenance of sevoflurane anesthesia. Methods Eighty-three patients with lung cancer in our hospital who wanted to undergo surgery were divided into a sevoflurane anesthesia group and a propofol anesthesia group by coin toss. The propofol anesthesia group (n=41 cases) was given propofol anesthesia during the operation Maintenance, sevoflurane anesthesia group (n=42 cases) was given intraoperative sevoflurane anesthesia for maintenance, and the changes in vital signs, serum protein, oxidative stress, anxiety, depression and cognitive function levels of the two groups of patients at different time periods after anesthesia were compared . Results The anesthesia, operation time and blood loss of the two groups were not statistically significant (P>0.05); HR, MAP, SOD, and MDA in the sevoflurane anesthesia group at T1 and T2 were lower than those in the propofol anesthesia group, and SOD and MDA were lower at T3 In the propofol anesthesia group, the MMSE scores at 6h and 1d after the operation were lower than those of the propofol anesthesia group, and the SDS and SAS scores at 1d after the operation were lower than the propofol anesthesia group (P<0.05). Conclusion Sevoflurane maintenance anesthesia is more conducive to the recovery of cognitive function in elderly patients after radical resection of lung cancer and reduces the occurrence of anxiety and depression. The mechanism is related to regulating serum S100β protein level, improving the bodys ability to resist oxidative stress, and enhancing brain protection.

[Keywords] sevoflurane; elderly; radical resection of lung cancer; oxidative stress; cognitive function; anxiety and depression