International Journal of Clinical Research

Objective The effect of combining botulinum toxin and non-crosslinked hyaluronic acid (Hi Body 2.5) in facial rejuvenation was investigated. Methods Sixty patients with facial aging or congenital soft tissue defects were randomly divided into two groups, each consisting of 30 individuals. The control group received non-crosslinked hyaluronic acid (Hyaluronic Acid 2.5) treatment, while the observation group was injected with botulinum toxin before receiving the non-crosslinked hyaluronic acid (Hyaluronic Acid 2.5) treatment. The improvement in both groups was recorded and compared. Results There was no significant difference in skin luster between the two groups (P>0.05); facial skin condition showed significant improvement compared to before treatment, and the data from the treatment group were higher than those of the control group (P<0.001); the total effective rate of facial wrinkle improvement in the observation group was 100%, significantly higher than the 76.67% in the control group (P=0.011). Conclusion Combining botulinum toxin and non-crosslinked hyaluronic acid (Hyaluronic Acid 2.5) can significantly improve facial aging, making the treatment method safer and more effective.

Botulinum toxin; Non crosslinked hyaluronic acid (Hi Ti 2.5); Facial rejuvenation; Wrinkle improvement