International Journal of Clinical Research

Abstract：Objective To explore the correlation between thyroid hormone levels and Child-Pugh classification and CLIF-C AD score in patients with acute decompensated cirrhosis.Methods 100 patients with acute decompensated cirrhosis admitted to the Second Affiliated Hospital of Dali University from January 2020 to December 2024 were retrospectively collected as the study group, and 100 cases of normal healthy medical checkups in the same period were selected as the control group.The clinical data and laboratory indexes of the two groups were collected and analyzed.The t-test was used between two groups for the measurements that conformed to normal distribution, and the ANOVA was used for the comparison between multiple groups; the Mann-Whitney U test was used for the comparison between groups for the measurements that did not conform to normal distribution.Pearson and Spearman correlation analyses were performed to analyze the thyroid hormone levels with Child-Pugh classification and CLIF-C AD score in patients with acute decompensated cirrhosis.Results T3, FT3, and TSH levels in the study group were significantly lower than those in the control group, all P<0.05; according to the etiologic grouping, T4 levels in the autoimmune cirrhosis group were higher than those in the viral cirrhosis group, the alcoholic cirrhosis group, and the cirrhosis of undetermined origin group, all P<0.05; in the acute decompensated events, the TSH levels in the dominant ascites group were significantly higher than those in the gastrointestinal bleeding group, all P<0.05; according to theChild-Pugh grading grouping, Child-Pugh grade A FT3 level was significantly higher than grade B and C, and Child-Pugh grade B FT3 level was higher than grade C, both P<0.05; according to CLIF-C AD score grouping, the low-risk group had a higher level of FT3 than the intermediate-risk and high-risk groups, and the intermediate-risk group had a significantly higher level of FT4 than the high-risk group, both P<0.05.Correlation analysis showed that liver function Child-Pugh grading was negatively correlated with FT3 (r=-0.460,P<0.05), and CLIF-C AD grouping in patients with acute decompensated cirrhosis was negatively correlated with FT3 (r=-0.410,P<0.05).Conclusion Patients with acute decompensated cirrhosis were accompanied by abnormal changes in thyroid hormone levels, and serum FT3 levels were closely related to the severity of their disease and prognosis.

Liver Cirrhosis; Acute decompensation; Thyroid hormone; Liver function score; Correlation