International Journal of Clinical Research

Objective To explore the results and correlation analysis of serum glycosylated protein (GSP) and glycosylated hemoglobin (HbA1c) in patients with type 2 diabetes (T2DM) at high altitude, and to clarify the practical value of their combined diagnosis. Methods 119 patients from the Department of Endocrinology of the Peoples Hospital of Hainan Prefecture (3000m above sea level) in Qinghai Province, 116 patients from the Department of Endocrinology of the Third Peoples Hospital of Xining City (2200m above sea level) and 200 patients from the diabetes Research Institute of Huashan Hospital affiliated to Fudan University in Shanghai (2.16m above sea level) were selected as the diabetes group, and 15 healthy people in the same period were selected as the control group. The data of their serum GSP, HbA1c, alanine aminotransferase (ALT), aspartate aminotransferase (AST). Results The expression levels of five serum indexes in patients with diabetes were higher than those in the control group (P<0.05); Correlation analysis showed a positive correlation (P<0.05) between serum GSP and all four indicators. Conclusion Serum GSP and HbA1c levels were significantly elevated in T2DM patients in high-altitude areas, and the two showed a positive correlation.

High-altitude areas; Type 2 diabetes; Serum glycated protein; Glycated hemoglobin; Correlation