International Journal of Clinical Research

Objective To analyze the efficacy of thrombolysis with alteplase (rt-PA) and Teneplase (TNK) in the treatment of acute cerebral infarction (ACI). Methods From February, 2024 to February, 2025, 112 patients with ACI in our hospital were selected, and the inclusion criteria were: confirmed patients with ACI; The onset time should be less than 4.5h; NIHSS<20 points. Exclusion criteria: there are signs of cerebral hemorrhage; Serious cardiovascular diseases; Coagulation dysfunction; Surgical treatment was performed recently. Randomly and equally, 56 cases in each group, the control group+RT-PA thrombolysis, the observation group+TNK thrombolysis, and the curative effect between groups was analyzed. Results After treatment, biochemical indexes, NIHSS (National Institutes of Health Stroke Scale) score and MBI(Barthel Index Classification) score between groups (P＞0.05); The curative effect and adverse reactions of the observation group were better than those of the control group (P＜0.05). Conclusion Thrombolysis with TNK and rt-PA in ACI patients is beneficial to the improvement of nerve and coagulation function and the ability of daily activities. Compared with rt-PA thrombolysis, TNK is more effective, safe and convenient.

Acute cerebral infarction; Adverse reactions; Tenecteplase; Therapeutic effect; Alteplase