International Journal of Clinical Research

Objective To explore the controllable risk factors influencing Alzheimers disease (AD) and provide corresponding measures for early prevention and intervention. Methods A 1:2 paired case-control study was used, 15 diagnosed AD patients were taken as the case group, and 30 non-AD normal elderly persons were collected as the control group; Chi-square test and multivariate Logistic regression were used to screen the influence of AD. Psychological factors of the patients morbidity. Results Multivariate analysis showed that less mental activity, more negative life events, less social activities and more depressive symptoms were independent risk factors for AD. Conclusion The promoting factors that affect the incidence of AD include more negative life events (OR=18.357), less social activities (OR=5.243) and less mental activity (OR=8.227), and the hindering factor is lack of depression (OR=0.045). In view of these modifiable independent factors, we should be vigilant and intervene and treat as soon as possible.

Alzheimers disease; Psychological factors; Controllable risk factors; Case-control study