International Journal of Clinical Research

Objective To investigate the mechanisms of coagulation disorders in patients who receive large volumes of blood transfusions during orthopedic surgery and to optimize transfusion strategies. Methods A total of 40 patients who underwent orthopedic surgery and received large volumes of blood transfusions at our hospital from January to December 2024 were selected for study. Blood samples were collected before, during, and after the transfusion to measure coagulation-related indicators, and the data were analyzed in conjunction with the patients clinical records. Results Before the transfusion, patients had normal PT, APTT, PLT, and Fg levels. During the transfusion, as blood was infused, PT and APTT began to increase, while PLT and Fg levels gradually decreased. Two hours after the transfusion, PT and APTT were significantly prolonged, and PLT and Fg levels were markedly reduced. The differences in these indicators during and after the transfusion were statistically significant compared to pre-transfusion levels (P<0.05). Conclusion Patients who receive large volumes of blood transfusions during orthopedic surgery have complex coagulation disorders. Optimizing transfusion strategies based on these findings can effectively improve patients coagulation function.

Orthopedic surgery; Massive blood transfusion; Coagulation dysfunction; Optimization of blood transfusion strategy