International Journal of Clinical Research

Objective To explore the application value and diagnostic efficacy of multi-parameter ultrasound elastography in the differentiation of benign and malignant thyroid nodules. Methods Two hundred patients with thyroid nodules admitted from January 2021 to January 2025 were selected. The postoperative pathological results were used as the gold standard and they were divided into the benign group and the malignant group. Ultrasound elastography was performed before the operation to record parameters such as Emean, Emax, Eratio, and SWV, and to evaluate conventional ultrasound features. T-test, χ² test and multivariate Logistic regression analysis were used to draw the ROC curve to evaluate the diagnostic efficacy. Results The Emean, Emax, Eratio, SWV and elasticity scores in the malignant group were significantly higher than those in the benign group (P<0.001). The conventional features such as microcalcification, unclear boundaries, and aspect ratio ≥1 showed statistically significant differences. Emax and Eratio are independent predictors. The AUC of the combined model reaches 0.938, which is significantly better than that of a single parameter. Conclusion Multi-parameter ultrasound elastography can effectively distinguish between benign and malignant thyroid nodules. Combined analysis can significantly improve diagnostic accuracy and has high clinical application value.

Ultrasonic elastography; Thyroid nodules; “Emax”; “Eratio”; Diagnostic efficacy