International Journal of Clinical Research

Objective To preliminarily investigate the short-term effects of the “4816 Nutritional Therapy System” in patients with overweight/obesity, type 2 diabetes, or hyperlipidemia. Methods This was a single-arm interventional study involving 48 patients diagnosed with at least one of the following conditions—overweight/obesity, type 2 diabetes, or hyperlipidemia—who received systematic dietary intervention at the Changqing Nutritional Therapy Center from March to December 2024. All participants completed a 12-week phased dietary intervention incorporating various components: time-restricted eating (16:8 protocol), high dietary fiber diet, low glycemic index (GI) diet, moderate carbohydrate energy ratio diet, energy-restricted diet, intermittent fasting (5:2 protocol), anti-inflammatory diet, and prebiotic fortification. Body weight, Body mass index (BMI) , fasting blood glucose (FBG) , glycated hemoglobin (HbA 1c ), total cholesterol (TC) , triglycerides (TG) , low-density lipoprotein cholesterol ( LDL-C ), and high-density lipoprotein cholesterol (HDL-C) were measured at baseline, week 5, and week 12. Changes in these indicators before and after the intervention were analyzed. Results All participants completed at least 5 weeks of intervention, with 31 cases (64 .6%) completing the full 12-week intervention protocol. After the intervention, participants showed significant reductions in BMI, FBG, HbA 1c, TC, TG, and LDL-C levels (P < 0.05). Conclusion A 12- week intervention using the “4816 Nutritional Therapy System” significantly improved body weight and glycemic and lipid metabolic parameters in patients with overweight/obesity, type 2 diabetes, or hyperlipidemia. These findings suggest a potential new dietary strategy for the management of these chronic conditions.

4816 nutritional therapy system; Type 2 diabetes; Hyperlipidemia; Blood glucose; Blood lipids