International Journal of Clinical Research

Objective To retrospectively compare the efficacy and safety of precut endoscopic mucosal resection (EMR-P) and endoscopic submucosal dissection (ESD) in treating small rectal neuroendocrine tumors (NETs). Methods Clinical data of 58 patients with small rectal NETs admitted to Tinghu District Peoples Hospital of Yancheng City from June 2020 to December 2024 were reviewed. The en bloc resection rate, pathological complete resection rate, curative resection rate, operation time, adverse event rate, and hospitalization time were compared between the EMR-P and ESD groups. Results The operation time in the EMR-P group was significantly shorter than that in the ESD group (P<0.05), and the median hospitalization time was also significantly shorter (P< 0.05). There were no significant differences in en bloc resection rate, pathological complete resection rate, or curative resection rate between the two groups. The adverse event rates showed no significant differences. After conservative treatment, the rates of delayed bleeding and delayed perforation improved in both groups. No significant differences were observed in vertical or horizontal margin positivity rates between the EMR-P and ESD groups. No local recurrence or metastasis was observed during follow-up in either group. Conclusion EMR-P is an effective and safe endoscopic treatment for rectal NETs with a diameter ≤10 mm. Compared to ESD, EMR-P significantly shortens operation and hospitalization times without increasing margin positivity rates.

Rectal neuroendocrine tumors; Endoscopic mucosal resection; Endoscopic submucosal dissection