孤独症患儿血清25(OH)D、叶酸水平及临床意义
Serum 25(OH)D, Folic Acid Levels and Clinical Significance in Children with Autism
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2021, 48(3) |
| 作者 |
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| 作者单位 |
洛阳市妇幼保健院 ;
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| 摘要 |
【摘要】探讨孤独症谱系障碍（ASD）患儿血清25羟维生素D[25(OH)D]、叶酸水平及临床意义。方法 纳入2018年2月-2020年2月我院200例ASD患儿，设为ASD组，并按病情分为轻中度（132）与重度组（68），选择年龄、性别配对的同期入院体检的200例正常儿童为对照组，比较两组血清25(OH)D、叶酸及叶酸代谢产物叶酸受体自身抗体(FRAA)以及5－甲基四氢叶酸(5-MTHF)水平。结果 ASD组血清25(OH)D、叶酸、5-MTHF水平显著低于对照组，FRAA水平、儿童孤独症评定量表（CARS）显著高于对照组，（P<0.05）；重度组血清25(OH)D、叶酸、5-MTHF水平显著低于轻中度组，FRAA水平、CARS评分显著高于轻中度组，（P<0.05）；血清25(OH)D、叶酸、5-MTHF水平与CARS评分呈负相关，FRAA水平与CARS评分呈正相关，（P<0.05）。结论 ASD的发病与病情进展可能与25(OH)D、叶酸缺乏以及代谢紊乱有关，可据此开展靶向营养或药物干预进行ASD的辅助治疗或预防。
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| Abstract |
[Abstract] Objective To explore the serum 25-hydroxyvitamin D [25(OH)D], folate levels and clinical significance of children with autism spectrum disorder (ASD). Methods A total of 200 children with ASD in our hospital from February 2018 to February 2020 were included in the ASD group, and divided into light moderate group (132) and severe group (68) according to the condition. 200 normal children who were admitted to the hospital during the same period of age and gender were selected as the control group. Serum 25(OH)D, folate and folate metabolite folate receptor autoantibodies (FRAA) and 5-methyltetrahydrofolate (5-MTHF) were compared between the two groups. Results The levels of serum 25(OH)D, folic acid and 5-MTHF in the ASD group were significantly lower than those in the control group, and the FRAA levels and Child Autism Rating Scale (CARS) were significantly higher than those in the control group (P<0.05). The levels of serum 25(OH)D, folic acid and 5-MTHF in the severe group were significantly lower than those in the mild-moderate group, and the FRAA levels and CARS scores were significantly higher than those in the mild-moderate group (P<0.05). Serum 25(OH)D, folic acid and 5-MTHF levels were negatively correlated with CARS scores, and FRAA levels were positively correlated with CARS scores (P<0.05). Conclusion The onset and progression of ASD may be related to 25(OH)D, folic acid deficiency, and metabolic disorders, which can be used to carry out targeted nutrition or drug intervention for adjuvant treatment or prevention of ASD.
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| 关键词 |
关键词：孤独症；25羟维生素D；叶酸；叶酸代谢
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| KeyWord |
Key words Autism; 25-hydroxyvitamin D; Folic Acid; Folate Metabolism
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| 基金项目 |
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| 页码 |
416-418 |
柳清梅*.
孤独症患儿血清25(OH)D、叶酸水平及临床意义 [J].
国际精神病学杂志.
2021; 48; (3).
416 - 418.