Journal of International Psychiatry

[Abstract] Objective To analyze the changes and significance of serum transient receptor potential channel 1 (TRPC1) levels in patients with vascular depression. Methods Eighty-three patients with vascular depression in our hospital from December 2016 to December 2019 were selected as the research objects. According to the Hamilton depression scale (HAMD), they were divided into low-grade depression group and high-grade depression group, and 40 healthy patients during the same period were selected. The physical examinee served as a control group. TRPC1 of different gender, age, and Montreal cognitive function assessment scale (MoCA) were compared among the three groups. Results According to the HAMD score, there were 35 cases in the high depression group and 48 cases in the low depression group. TRPC1 (562.78±69.45) pg/ml in the high-depression group was significantly lower than TRPC1 (659.53±84.60) pg/ml in the low-depression group and TRPC1 (738.61±95.72) pg/ml in the control group. The differences were statistically significant. Significance (P<0.05). The TRPC1 of different genders and ages in the high-depression group was significantly lower than that of the low-depression group and the control group. The TRPC1 of the high-depression group with MoCA<21 points and MoCA 21~26 points was significantly lower than that of the low-depression group with statistical differences. Significance (P<0.05). There was no significant difference in TRPC1 among the three groups with MoCA>26 points (P>0.05). Conclusion The TRPC1 of patients with vascular depression can decrease with the increase of depression degree and age, and decrease with the decline of cognitive function. Clinically, the degree of depression and cognitive function of patients can be evaluated.

Key words Vascular Depression; TRPC1; Gender; Age; MoCA