Journal of International Psychiatry

[Abstract] Objective To analyze the changes of mental state and neurological function in patients with depression after acute ischemic stroke after ozagrel sodium combined with fluoxetine treatment. Methods The 113 patients with acute ischemic post-stroke depression admitted to this hospital were divided into 56 cases in the conventional western medicine group and 57 cases in the combined western medicine group by coin tossing. Patients in the combination group were treated with fluoxetine and continued treatment for 12 weeks. The neurological function, depression, inflammatory factors, quality of life, and drug safety after treatment were compared. Results After 4, 8, and 12 weeks of treatment, the NIHSS score and hs-CRP level of the western medicine combination group were lower than those of the conventional western medicine group. After 12 weeks of treatment, the Barthel index was higher than that of the conventional western medicine group, and the SDS score was lower than that of the conventional western medicine group (P< 0.05); the adverse reactions between the two groups were not statistically significant (P>0.05). Conclusion Fluoxetine combined with ozagrel sodium can effectively eliminate the negative emotions of patients with post-stroke depression, promote the recovery of neurological function, and significantly improve the quality of life of patients with acute ischemic stroke depression, with high safety.

[Keywords] fluoxetine; ozagrel sodium; acute ischemic stroke; depression; neurological function; mental state