帕罗西汀对COPD合并焦虑抑郁患者情绪及肺功能的影响
Effect of Paroxetine on Mood and Lung Function in Patients with COPD and Anxiety and Depression
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2020, 47(6) |
| 作者 |
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| 作者单位 |
平煤神马医疗集团总医院呼吸与危重症医学科 ;
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| 摘要 |
【摘要】探讨帕罗西汀对慢性阻塞性肺疾病（COPD）合并焦虑抑郁患者情绪及肺功能的影响。方法 本研究对象为2019年2月~2020年2月我院94例COPD急性加重期合并焦虑抑郁患者，数字表法随机均分为两组，对照组进行COPD急性加重期常规治疗，观察组在此基础上联合帕罗西汀治疗。比较两组患者治疗前后抑郁自评量表（SDS）、圣乔治呼吸问题调查问卷( SGRQ)、焦虑自评量表（SAS）、用力呼气容积( FVC) 、1s用力呼气量（FEV1）以及6分钟步行距离（6MWT）。结果 治疗后两组SAS评分、SDS评分、SGRQ评分均显著降低，治疗后观察组显著低于对照组，（P<0.05）；治疗后两组FEV1、FVC、6MWT均显著升高，治疗后观察组6MWT、FEV1、FVC均显著高于对照组，（P<0.05）。结论 帕罗西汀辅助治疗能显著改善COPD合并焦虑抑郁患者不良情绪以及生活质量，能够提升患者的步行能力，有助于急性加重期患者肺功能的改善。
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| Abstract |
[Abstract] Objective To explore the effect of paroxetine on the mood and lung function of patients with chronic obstructive pulmonary disease (COPD) combined with anxiety and depression. Methods Ninety-four patients with anxiety and depression in the acute exacerbation of COPD in our hospital from February 2019 to February 2020 were the subjects of this study. They were randomly divided into two groups by the number table method. The control group received conventional treatment for acute exacerbation of COPD, and the observation group was treated with paroxetine on this basis. The two groups were compared before and after treatment on the self-rating depression scale (SDS), St. George’s respiratory problem questionnaire (SGRQ), self-rating anxiety scale (SAS), forced expiratory volume (FVC), forced expiratory volume in 1s (FEV1) and 6 minutes walking distance (6MWT). Results After treatment, the SAS score, SDS score and SGRQ score of the two groups were significantly reduced, and the observation group was significantly lower than the control group after treatment (P<0.05). After treatment, FEV1, FVC, and 6MWT in the two groups were significantly increased. After treatment, 6MWT, FEV1 and FVC in the observation group were significantly higher than those in the control group (P<0.05). Conclusion Paroxetine adjuvant therapy can significantly improve the bad mood and quality of life of patients with COPD combined with anxiety and depression, can improve the walking ability of patients, and help improve the lung function of patients in acute exacerbations.
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| 关键词 |
关键词：帕罗西汀;COPD;焦虑抑郁;情绪;肺功能
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| KeyWord |
Key words Paroxetine; COPD; Anxiety and Depression; Emotions; Lung Function
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| 基金项目 |
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| 页码 |
1181-1183 |
雷凯春*.
帕罗西汀对COPD合并焦虑抑郁患者情绪及肺功能的影响 [J].
国际精神病学杂志.
2020; 47; (6).
1181 - 1183.