| Abstract |
[Abstract] Objective To analyze the changes in the psychological state and physiological stress response of patients after cervical cancer surgery after receiving sufentanil combined with low-dose ketamine-controlled intravenous analgesia (PCIA). Methods In the future, 89 cases of cervical cancer patients treated in our hospital were divided into single-agent analgesia group 44 cases and combined analgesia group 45 cases by coin toss. Patients in the single-agent analgesia group were given sufentanil analgesia and combined analgesia. Patients in the pain group increased low-dose ketamine combined with analgesia, and compared the poor mental state (anxiety and depression), analgesic effects (PCIA compressions, pain score and sedation score), and stress response [cortisol (Cor)] , Epinephrine (E) and Norepinephrine (NE)] and the incidence of postoperative complications. Results The number of PCIA compressions, NE, Cor, E levels, NRS, SAS-20, SDS-20 scores and complication rates in the combined analgesia group were lower than those in the single-agent analgesia group, and the Ramsay score was higher than the control group (P<0.05) . Conclusion Low-dose ketamine combined with sufentanil PCIA can effectively reduce postoperative pain of cervical cancer, with significant analgesic effect, alleviating stress response, alleviating postoperative anxiety and depression, and low postoperative adverse reactions.
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