| Abstract |
[Abstract] Objective To explore the impact of the severity of depression on cognitive function and event-related potentials (ERP-P300). Methods Eighty-four patients with depression in our hospital from February 2018 to February 2020 were selected. According to the Hamilton depression scale (HAMD) ≥24 points and <24 points, they were set as the severe group and the mild-moderate group, with 28 cases and 56 cases respectively. During the same period, 40 healthy people matched with general data were selected as the control group. The repetitive neuropsychological status test (RBANS) was used to evaluate cognitive function, to measure the amplitude and latency of ERP-P300 P3a, P3b, and N2, and to analyze the correlation of each index. Results The HAMD score of the severe group was significantly higher than that of the mild-moderate group and the control group, and the light-moderate group was significantly higher than the control group. The dimensions and total scores of RBANS were significantly lower than the mild-moderate group and the control group. The mild-moderate group was significantly lower than the control group (P<0.05). The amplitude of P3a, P3b, and N2 in the severe group was significantly lower than that of the mild-moderate group and the control group, the mild-moderate group was significantly lower than the control group, the incubation period was significantly higher than the mild-moderate group and the control group, and the mild-moderate group was significantly higher than the control Group (P<0.05). HAMD score is significantly negatively correlated with RBANS score, HAMD score is negatively correlated with P3a, P3b, and N2 amplitude, and positively correlated with P3a, P3b, and N2 latency. RBANS score is positively correlated with P3a, P3b, and N2 amplitude, and is positively correlated with P3a, P3b, and P3b. N2 latency was negatively correlated (P<0.05). Conclusion Patients with depression have different degrees of cognitive impairment, and the higher the degree of depression, the more severe the cognitive impairment. ERP-P300 can reflect the cognitive impairment of depression.
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