| Abstract |
【Abstract】Objective To study the expression of vascular endothelial function in elderly patients with coronary heart disease complicated with anxiety disorder and its influence on prognosis.Methods According to the results of self rating Anxiety Scale (SAS), 80 patients with coronary heart disease were divided into anxiety group (n = 45) and non anxiety group (n = 35). Meanwhile, anxiety group was divided into three subgroups: mild anxiety group (n = 21), moderate anxiety group (n = 13) and severe anxiety group (n = 11), RHI, EPCs,ET-1CK-MB, AST, hs CRP, CAM-1, the correlation between SAS score and the above indicators in anxiety group was compared, and the prognosis of the two groups was observed.Results The levels of RHI and EPCs in the non anxiety group and mild anxiety group were significantly higher than those in the moderate and severe anxiety groups, and the ET-1 level was significantly lower than that in the moderate and severe anxiety groups (P < 0.05). The levels of CK-MB, hs CRP and cam-1 in non anxiety group and mild anxiety group were significantly lower than those in moderate and severe anxiety groups (P < 0.05).By correlation analysis, SAS score was negatively correlated with RHI and EPCs, and positively correlated with ET-1, CK-MB, hs CRP and cam-1 (P < 0.05).The incidence of non fatal myocardial infarction and stroke in anxiety group was significantly lower than that in non anxiety group (P < 0.05).Conclusion Anxiety disorder may change disease progression by affecting vascular endothelial function and myocardial enzyme expression in elderly patients with coronary heart disease, and the risk of poor prognosis is higher.
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