Journal of International Psychiatry

Bipolar disorder is a common type of mental disorder, and its pathogenesis and pathophysiological changes are still unclear. In recent years, there is evidence that the neuroimmune system may be involved in the pathological process of BD. BD is involved in the activation of immune cells and the release of inflammatory substances in the central nervous system, but its internal connection is not completely clear. The levels of C-reactive protein, pro-inflammatory cytokines(such as IL-1，IFN-γ，IL-6，TNF-α) and anti-inflammatory cytokines(such as IL-4、IL-10、TGF-β) in the peripheral blood of BD patients are abnormal, and the levels are significantly different in different genders, emotional states and disease stages. In addition, weight, comorbidities and drug treatment will also affect the level of relevant markers. Clarifying the role of neuroimmunity in the pathogenesis of BD has potential value for the clinical diagnosis, prognosis and predicting drug efficacy of BD.

Bipolar disorder; C-Reactive protein; Inflammatory factor; Cytokine