Journal of International Psychiatry

[Abstract] Objective: To investigate the effects of apatinib mesylate combined with MBSR on cancer-induced fatigue, self-efficacy and tumor vascular growth factor in patients with advanced ovarian cancer. Methods: random number table method is used to select 2018 during July to September 2020, 115 cases of advanced ovarian cancer patients as the research object, 57 cases were treated more west he injection combined cisplatin injection, 58 cases in the control group therapy on the basis of the observation group joint mesylate path for piece and MBSR, observe two groups of patients with cancer-related fatigue, self-efficacy and tumor vascular growth factors. Results: After treatment, the degree of cancer-related fatigue and self-efficacy in both groups were improved, and the improvement in the observation group was higher than that in the control group (P < 0.05). After treatment, tumor vascular growth factor was reduced in both groups compared with that before treatment, and the reduction in the observation group was higher than that in the control group (P < 0.05). Conclusion: Apatinib mesylate combined with mindfulness based stress reduction therapy in the treatment of advanced ovarian cancer patients has a definite effect, can effectively inhibit the growth of tumor cells, effectively relieve the physical and psychological pressure of patients, and improve patients cancer-related fatigue and self-efficacy, which is worthy of clinical promotion.

[Key words] Apatinib mesylate; Mindful stress reduction; Advanced ovarian cancer; Cancer induced fatigue; Tumor vascular growth factor