Journal of International Psychiatry

Objective: To investigate differences in cognitive function in patients at ultra-high-risk for psychosis (UHR) with and without sleep disturbances. Method: Totally 97 subjects with ultra-high-risk for psychosis were recruited and assessed with the Repeatable Batter for the Assessment of Neuropsychological Status (RBANS) for cognition function, and Pittsburgh sleep quality index (PSQI) for sleep. Results: Visual span and cognitive total scores of the UHR group with sleep disorder were significantly lower than UHR group without sleep disorder (P<0.05). The Pittsburgh sleep quality index was negatively correlated with immediate memory, attention, and cognitive scores (r=-0.35, P<0.001; r=-0.39, P= 0.001; r=-0.38, P<0.001), but there were no statistically significant differences in terms of visual breadth, speech and delayed memory (P>0.05). Conclusion: Cognitive impairment was more severe in patients at high risk of schizophrenia with sleep disturbance than in patients without sleep disturbance, and sleep disturbance may aggravate cognitive impairment in patients at high risk of schizophrenia.

Schizophrenia; Ultra high risk; Cognitive function; Sleep