| 摘要 |
探讨共病糖尿病对慢性精神分裂症患者体质量指数、血脂水平、整体功能及认知功能各维度的影响。方法 收集2017年7月至2019年7月在上海市嘉定区某专科医院住院的患者，共342例，分为共病糖尿病组（61例）和无糖尿病组（281例），采集一般资料、身高、体重、血脂相关指标，应用功能大体评定量表(GAF)进行功能水平测试，应用认知功能成套测验-共识版(MCCB)进行认知功能水平测试，比较两组间的差异，并进行相关分析。结果 ⑴共病组患者住院天数显著高于非共病组（z = -2.64, P < 0.01）；(2)共病组较非共病组，其GAF功能、HDL明显偏低（t = -4.73, P< 0.01; t = -3.33, P < 0.01），BMI明显偏高（t = 2.23, P < 0.05）；(3)共病组患者在连线测验，空间广度项目得分较低，两组差异有统计学意义（t = 2.31, P < 0.05；t = 2.33, P < 0.05）；(4)共病糖尿病的患者的整体功能与连线测验、空间广度呈正相关（r = 0.518，P < 0.05；r = 0.530，P < 0.05），而与BMI呈负相关（r = -0.148，P < 0.05）。结论 共病糖尿病的长期住院精神分裂症患者肥胖程度更高，血脂异常明显，住院周期更长，认知功能及整体功能受损更为严重,需要我们积极控制血糖，以改善不良预后。
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| Abstract |
Objective To investigate the effects of diabetic comorbidity on Body Mass Index, blood lipid level, global functioning and the cognitive function with chronic schizophrenia. Methods A total of 342 patients who were hospitalized in Shanghai jiading from July 2016 to July 2018 were divided into the diabetic group (61 cases) and the non-diabetic group (281 cases). Medical record, height, weight and blood lipid were collected, Global Assessment of Functioning Scale (GAF) and MATRICS Consensus Cognitive Battery (MCCB) were conducted to compare the differences between the two groups, and then the relevant analysis was carried out. Results (1) Hospitalization days in schizophrenia patients with comorbid diabetes (study group) was significantly longer than that of the patients with no diabetes (control group) (z = -2.64, P < 0.01); (2) GAF score and High Density Lipoprotein (HDL) was significantly lower in study group than that in control group （t = -4.73, P < 0.01; t = -3.33, P < 0.01）， while BMI were significantly higher in study group than those in control group (t = 2.23, P < 0.05). (3)Both the line test and spatial span were with lower scores in study group, there were significant differences between the two groups（t = 2.31, P<0.05；t = 2.33, P<0.05）. (4)The global function of patients with comorbidities was positively correlated with connection test and spatial span（r = 0.518，P < 0.05；r = 0.530，P < 0.05）, but negatively correlated with BMI（r = -0.148，P < 0.05）. Conclusion High BMI, obvious dyslipidemia, longer hospitalization period, serious global functional impairment and cognitive function impairment, will be more likely appeared in chronic schizophrenia with comorbid diabetes. We need to pay more attention to control blood sugar in order to improve the poor prognosis.
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