Journal of International Psychiatry

Drug induced cardiovascular complications are the main cause of death in patients with mental illness. Typical or atypical antipsychotics can induce or lead to their occurrence. Clozapine, as the second generation of antipsychotics, plays an important role in the treatment of refractory psychosis and schizophrenia with negative symptoms. Previous studies have shown that clozapine can induce or promote deep vein thrombosis and pulmonary embolism. This reminds clinicians to pay more attention to the possibility of pulmonary embolism caused by the second generation antipsychotics, correct the wrong medication habits, avoid the risk factors and reduce the occurrence of related serious consequences. This article intends to discuss the correlation between clozapine and pulmonary embolism, aiming to sort out the causes and risk factors of clozapine induced pulmonary embolism in patients with refractory psychosis, and put forward some constructive suggestions on targeted preventive measures.

Clozapine; refractory psychosis; pulmonary embolism