Journal of International Psychiatry

Objective: To explore the difference of curative effect and prognosis of first-episode schizophrenic patients in different age groups. Methods: 110 first-episode schizophrenic patients were divided into three groups: early onset group (≤ 25 years old), young and middle-aged group (> 25 years old, ≤ 50 years old), late onset group (> 50 years old). Positive and negative symptom scale (PANSS) was used to evaluate the efficacy All patients were treated with risperidone orally disintegrating tablets . The dosage of risperidone orally disintegrating tablets at discharge and the PANSS score reduction rate after 30 days of systematic treatment were compared to evaluate the therapeutic effect of patients. Two years later, the positive and negative symptom scale (PANSS) and general functional assessment scale (GAF) scores of the three groups were compared and analyzed to evaluate whether there were differences in the prognosis of the three groups after two years. Results: the PANSS score of the early onset group at admission was higher than that of the young and middle-aged group and the late onset group, and the difference was statistically significant (P < 0.01, P < 0.05). After 30 days of treatment, the PANSS score reduction rate of the young and middle-aged group was higher than that of the early onset group, P < 0.05, and the dosage of risperidone orally disintegrating tablets of the young and middle-aged group was lower than that of the early onset group, P < 0.05. Two years later, the GAF score of the young and middle-aged group was higher than that of the early-onset group and the late-onset group, with statistical difference, P < 0.01, and the PANSS score of the young and middle-aged group and the late-onset group was lower than that of the early-onset group, P < 0.05. Conclusion: the curative effect and prognosis of first-episode schizophrenia in different age groups are different.

Age group; First episode; Schizophrenia; Curative effect; Prognosis