Journal of International Psychiatry

[Abstract]Objective: To explore the effects of agormelatin on depression and sleep quality in patients with postpartum depression and sleep disorders. Methods: 2018-1-2020-5 Patients with postpartum depression and sleep disorders were divided into two groups according to random sampling method, 61 patients in the control group were given oral paroxetine, 62 patients in the observation group were given agomelatin orthopaedic, and serum oxidative stress factors, depression, sleep quality and drug safety were compared with two groups of patients at the end of 3 months. Results: MDA level decreased and SOD level increased after treatment in both groups, but the decline and increase in the observation group were higher than that of the control group (P<0.05); The total< rate of adverse reactions in the observation group was 3.23% (2/62) lower than that in the control group of 8.20% (5/61) (p>0.05). Conclusion: The effect of aggomeilatin in treating postpartum depression with sleep disorder is accurate, which can significantly relieve the patients depression, improve the patients sleep quality, reduce the serum oxidative stress factor in the patients body, is safe and reliable, and is worthy of clinical promotion and use.

[Key words]: agomelatin; postpartum depression with sleep disorders; depression; sleep quality