| Abstract |
[Abstract] Objective To explore the effect of depression on serum inflammatory markers and endothelial function of coronary heart disease. Methods A total of 150 patients with coronary heart disease in our hospital from June 2017 to June 2020 were selected as the study subjects. The Hamilton Depression Scale (HAMD) was used to evaluate the degree of depression of the patient on the second day of admission, and were set as the depression group and the non-depression group. The serum inflammation markers were detected, including interleukin 6 (IL-6), IL-18, tumor necrosis factor (TNF-α), etc. The endothelial function-related indicators were detected, including vascular endothelin 1 (ET-1), nitric oxide (NO), thromboxane B2 (TXB2), 6-keto-prostaglandin F1α (6-keto-PGF1α), etc. The correlation between HAMD score and serum inflammation markers and endothelial function indicators were analyzed. Results Forty-five cases of depression detected in 150 patients with coronary heart disease, and the levels of serum IL-6, IL-18 and TNF-α in the depression group were significantly higher than those in the non-depression group, and the difference was statistically significant (P<0.05). The levels of serum ET-1 and TXB2 in the depression group were significantly higher than those in the non-depressive group, and the levels of NO and 6-keto-PGF1α were significantly lower than those in the non-depressive group. The difference was statistically significant (P<0.05). HAMD score was positively correlated with the levels of IL-6, IL-18, TNF-α, ET-1, TXB2, and negatively correlated with the levels of NO and 6-keto-PGF1α, (P<0.05). Conclusion The detection rate of depression in patients with coronary heart disease is higher, and the combination of depression will enhance the inflammatory response of patients with coronary heart disease and aggravate the damage of endothelial function.
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