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[Abstract] Objective To investigate risk factors for early cognitive dysfunction in patients with respiratory failure. Methods A total of 150 patients with respiratory failure from November 2018 to October 2020 in our hospital were selected as the investigation subjects, and their cognitive function was evaluated using the Montreal Cognitive Assessment Scale (MoCA), and those with a total score > 26 points were classified as the normal group, and those with a total score ≤ 26 points were classified as the impaired group.The basic data, acute physiology and chronic health score (APACHCE-II), sequential organ failure assessment (SOFA), brain natriuretic peptide (BNP), and lung function were compared between the two groups. Results Of the 150 patients, 62 had a MOCA total score > 26 points and 88 had a MOCA total score ≤ 26 points. There were no significant differences in gender, weight, disease duration, smoking history, alcohol abuse or type of respiratory failure between the two groups (P > 0.05). The normal group showed significantly lower age, rate of neurocentral disease, APACHCE-II, SOFA and BNP than the impaired group, all of which were significant different (P < 0.05).FEV1, FVC, and PEFR were significantly higher in the normal group than in the impaired group, all P < 0.05.After multivariate logistic regression analysis, age > 60 years, neuro central disease, APACHCE-II score > 50, SOFA > 15, BNP > 60pg / ml, FEV1 ≤ 50% and FVC ≤ 2L were all risk factors for early cognitive impairment in patients with respiratory failure (P < 0.05), and PEFR ≤ 3L / min was not associated with early cognitive impairment in patients with respiratory failure (P > 0.05). Conclusion Early cognitive impairment in patients with respiratory failure was significantly associated with advanced age, presence of neuropathy, excess BNP, and lower lung function.
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