| Abstract |
Objective To investigate the effects of aripiprazole on the serum non-enzymatic antioxidants and information processing speed of patients in acute episode of schizophrenia. Methods From March 2017 to January 2020, 92 schizophrenia patients in acute episode were enrolled and finished 6 weeks treatment with aripiprazole. Before and after treatment, positive and negative syndrome scale (PANSS) was used to evaluate the clinical symptoms, symbolic coding (SC) and Stroop color-word test (SCWT) were used to evaluate the information processing speed. Serum albumin (ALB), total bilirubin (TBIL) and uric acid (UA) concentrations were also detected. The differences of serum non-enzymatic antioxidant concentration and information processing speed were compared before and after treatment. Further analyses of relationships between non-enzymatic antioxidant, information processing speed and treatment responses were conducted. Results 1. The total PANSS scores (t=-22.74, P<0.001), ALB (t=-2.46, P=0.016), TBIL (t=-3.88, P<0.001) and UA (t=-5.23, P<0.001) all decreased significantly after treatment. SC (t=9.52, P<0.001) and SCWT scores (t=9.70, P<0.001) significantly improved. 2. Divided the sample into treatment response and non-response group by reducing rate of PANSS, repeated measures analysis of variance showed that there were significant main effects of time on ALB, TBIL, UA, SC and SCWT (all P<0.001), with no significant main effect of group or time*group interaction (all P>0.05). Conclusions Aripiprazole can affect serum non-enzymatic antioxidant and cognitive function in acute episode of schizophrenia, and these processes may be not related to treatment response.
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