International Journal of Nursing Research

Objective To analyze the impact of shortening the door-to-needle time (DNT) on the prognosis of patients with acute cerebral infarction undergoing intravenous thrombolysis. Methods A total of 374 patients with acute cerebral infarction who received intravenous thrombolysis within 6 hours of onset from January 2023 to June 2024 in our hospital were included in the study. Patients were divided into two groups based on DNT: the control group (DNT > 60 min, 50 patients) and the experimental group (DNT ≤ 60 min, 324 patients). The neurological function, oxidative stress, and prognosis of the two groups were assessed and compared. Results The National Institutes of Health Stroke Scale (NIHSS) scores of both groups showed a significant decrease from before thrombolysis to 24 hours and 14 days after thrombolysis, with the experimental group having lower NIHSS scores at 24 hours and 14 days after thrombolysis (P < 0.05). There was no significant difference in the level of oxidative stress indicators between the two groups before thrombolysis (P > 0.05). The overall level of the modified Rankin Scale (MRS) score at 90 days after thrombolysis was lower in the experimental group than in the control group (P < 0.05). Compared with before thrombolysis, the levels of superoxide dismutase (SOD) increased and malondialdehyde (MDA) decreased in both groups after thrombolysis, with the experimental group having higher SOD levels and lower MDA levels than the control group (P < 0.05). The mortality rate and the rate of fatal cerebral hemorrhage were significantly lower in the experimental group compared to the control group (P < 0.05). Conclusion These findings indicate that the shorter the DNT, the better the prognosis of patients with acute cerebral infarction, and shortening the DNT is beneficial for improving neurological function and oxidative stress indicators in patients.

Acute cerebral infarction; Intravenous thrombolysis; Door-to-needle time; Prognosis