| Abstract |
Objective: To explore the relationship between the changes of brain electrophysiological signals and depressive symptoms during the intermission of temporal lobe epilepsy. Methods: 26 patients with temporal lobe epilepsy who underwent surgery in Guangdong Sanjiu brain hospital from 2016 to 2018 were retrospectively analyzed. The EEG signals of epileptogenic interval were collected by stereotactic electroencephalogram (SEEG), and the depression symptoms were evaluated by HAMD-24. Results: 1) the total score of HAMD-24 was significantly correlated with absolute mean amplitude, standard deviation of amplitude, total power of whole frequency band, delta power and theta power of anterior middle temporal gyrus (r = 0.479, P = 0.018; r = 0.486, P = 0.016; r = 0.414, P = 0.044; r = 0.439, P = 0.032; r = 0.410, P = 0.046); 2) the sleep factor of HAMD-24 was significantly correlated with absolute mean amplitude, amplitude standard deviation of amplitude, full band total power, alpha power and delta power of anterior middle temporal gyrus were (r = 0.463, P = 0.023; r = 0.469, P = 0.021; r = 0.441, P = 0.031; r = 0.453, P = 0.026; r = 0.453, P = 0.026); 3) there were significant differences in the absolute mean and standard deviation of SEEG amplitude in the anterior part of the middle temporal gyrus between the group without depression and the group with depression (t = 2.18, P = 0.04; t = 2.21，P=0.04). Conclusion: the variability of lateral temporal lobe EEG power during the intermission of temporal lobe epilepsy may be related to depression and sleep symptoms, which provides neurophysiological evidence for the pathological mechanism of depression in patients with temporal lobe epilepsy.
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