初乳口腔免疫疗法对NICU患儿疗效的Meta分析-国际护理学研究-CSCIED科技核心评价数据库-手机版

初乳口腔免疫疗法对NICU患儿疗效的Meta分析

Efficacy of colostrum oral immunotherapy in neonatal intensive care unit: a Meta-analysis

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DOI	10.12208/j.ijnr.20250287
刊名	国际护理学研究 International Journal of Nursing Research
年，卷(期)	2025, 7(6)
作者	周曦*,张虹,
作者单位	西安交通大学第一附属医院新生儿科陕西西安
摘要	目的通过meta分析的方法探讨初乳口腔免疫疗法对NICU患儿临床结局的影响。方法系统检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、Embase、Cochrane Library、PubMed、Web of Science 数据库发表的有关NICU患儿应用初乳口腔免疫疗法的文献，检索时限为建库至2025年3月，应用Revman 5.3软件进行统计分析。结果最终纳入9篇文献，其中中文文献4篇，英文文献5篇，纳入患者共1101例。Meta分析结果显示，初乳口腔免疫疗法能降低NICU患儿并发症发生率［RR=0.60，95％CI（0.36，0.99），P=0.05，］，缩短住院时间［RR=-4.51，95％CI（-4.68，-4.35），P＜0.05］，但对病死率［RR=0.79，95％CI（0.54，1.14），P＞0.05］及降低NEC的发生率［RR=0.83，95％CI（0.38，1.79），P＞0.05］无显著作用。结论初乳口腔免疫疗法可以降低NICU患儿并发症发生率，缩短住院时间，但对患者的病死率和NEC的发生率无显著影响。
Abstract	Objective To study the effect of colostrum oral immunotherapy on the clinical outcome of neonates in neonatal intensive care unit (NICU) by Meta-analysis. Methods CNKI, Wanfang Database, VIP database, Chinese Biomedical Literature Database, Embase, Cochrane Library, PubMed, and Web of Science databases were searched for studies on colostrum oral immunotherapy in neonates in NICU. The retrieval time was from the establishment of the database to March 2025. Revman 5.3 software was used for statistical analysis. Results A total of 9 studies (4 Chinese and 5 English) involving 1101 patients were included. Conclusions of Meta-analysis. The results showed that colostrum oral immunotherapy could reduce the incidence of complications [RR=0.60, 95%CI (0.36, 0.99), P=0.05], shorten the length of hospital stay [RR=-4.51, 95%CI (-4.68, -4.35), P < 0.05], but had significant effect on mortality [RR=0.79, P < 0.05]. 95% CI (0.54, 1.14), P > 0.05] and the incidence of NEC [RR=0.83, 95% CI (0.38, 1.79), P > 0.05]. Conclusions Colostrum oral immunotherapy can reduce the incidence of complications and shorten the length of hospital stay in NICU, but has no significant effect on the mortality and the incidence of NEC.
关键词	初乳；口腔免疫疗法；meta分析
KeyWord	Colostrum; Oral immunotherapy; Meta-analysis
基金项目
页码	4-9

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引用本文

周曦*,张虹. 初乳口腔免疫疗法对NICU患儿疗效的Meta分析 [J]. 国际护理学研究. 2025; 7; (6). 4 - 9.

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