马来酸氟伏沙明治疗老年抑郁患者的效果及对不良心理状态与自杀风险的影响
The effect of fluvoxamine maleate in the treatment of elderly patients with depression and its influence on the adverse mental state and suicide risk
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2022, 49(2) |
| 作者 |
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| 作者单位 |
商丘市第二人民医院精神科八病区 ;
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| 摘要 |
【摘要】 探究马来酸氟伏沙明治疗老年抑郁患者的效果及对不良心理状态与自杀风险的影响。方法 纳入我科老年抑郁患者105例，对照组52例给予氟西汀治疗，观察组53例给予马来酸氟伏沙明治疗，治疗后对比两组患者不良心理状态、自杀风险、家庭负担、生活质量及安全性。结果 治疗后，观察组汉密尔顿抑郁量表(HDRS-17)评分、自杀意念自评量表(SIOSS)评分水平相较于对照组低（P＜0.05）；家庭负担访谈问卷(FEIS)评分相较于对照组高（P＜0.05）；副反应量表（TESS）评价相较于对照组低（P＜0.05）；生理职能、生理功能、精神健康、情感职能、社会功能、总体健康6项方面评分水平均较对照组高（P＜0.05）。结论 马来酸氟伏沙明应用于老年抑郁患者中可有效改善患者心理状态，降低自杀风险、减轻家庭负担、提高生活质量水平，安全性较高。
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| Abstract |
【Abstract】 Objective To explore the effect of fluvoxamine maleate in the treatment of elderly depressed patients and its influence on the adverse mental state and suicide risk. Methods A total of 105 elderly depression patients in our department were enrolled. 52 cases in the control group were treated with fluoxetine, and 53 cases in the observation group were treated with fluvoxamine maleate. After treatment, the two groups were compared with poor mental status, suicide risk, family burden, Quality of life and safety. Results After treatment, the Hamilton Depression Scale (HDRS-17) score and the suicide ideation self-rating scale (SIOSS) score of the observation group were lower than those of the control group (P＜0.05); the family burden interview questionnaire (FEIS) score was relatively lower High in the control group (P＜0.05); the side effect scale (TESS) evaluation is lower than that in the control group (P＜0.05); six aspects of physiological function, physiological function, mental health, emotional function, social function and general health The score level was higher than that of the control group (P＜0.05). Conclusion Fluvoxamine maleate used in elderly depressed patients can effectively improve the mental state of the patients, reduce the risk of suicide, reduce the psychological burden, and improve the quality of life. It is safer.
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| 关键词 |
【关键字】马来酸氟伏沙明；氟西汀；老年抑郁；心理状态；自杀风险
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| KeyWord |
[Keywords] fluvoxamine maleate; fluoxetine; senile depression; mental state; suicide risk
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| 基金项目 |
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| 页码 |
227-229 |
张秋云*.
马来酸氟伏沙明治疗老年抑郁患者的效果及对不良心理状态与自杀风险的影响 [J].
国际精神病学杂志.
2022; 49; (2).
227 - 229.