重复经颅磁刺激对轻度认知功能障碍患者认知功能和心理状态影响
The effects of repetitive transcranial magnetic stimulation on cognitive function and psychology in patients with mild cognitive Impairment
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| DOI |
| 刊名 |
Journal of International Psychiatry
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| 年，卷(期) |
2021, 48(6) |
| 作者 |
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| 作者单位 |
沈阳市精神卫生中心 ;
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| 摘要 |
【摘要】目的：探讨重复经颅磁刺激(rTMS)对轻度认知功能障碍(MCI)患者认知功能和心理状态的影响。方法：选取2020年1月~2020年12月在我院门诊就诊的40例MCI患者，按照数字表法随机分为研究组20例和对照组20例，研究组接受系统的 rTMS 治疗，对照组接受伪刺激，共8 w。在基线、治疗4周后和治疗8周后应用汉密尔顿抑郁量表（HAMD）、简易精神评定量表（MMSE）、蒙特利尔认知评估量表（MoCA）评定患者的情绪和认知状况。结果：治疗前，两组HAMD、MMSE、MoCA评分差异无统计学意义(P＞0.05)；治疗4周和8周后，对照组HAMD、MMSE、MoCA评分与基线评分比较差异无统计学意义(P＞0.05)；研究组HAMD评分低于治疗前，且8周后得分低于4周后得分，MMSE、MoCA评分均高于基线评分(P均＜0.05)，且治疗8周后MMSE、MoCA评分均高于治疗4周后(P均＜0.05)。治疗后，两组未出现明显不良反应。结论：rTMS 可促进MCI患者认知功能恢复和改善抑郁情绪，且治疗8周后认知功能恢复优于治疗4周后，安全性高。
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| Abstract |
To investigate the effects of rTMS on cognitive function and psychology mild cognitive Impairment inpatients. Methods: 40 MCI patients in our hospital from January 2020 to December 2020 were randomly divided into 20 cases in the study group and 20 control group according to the number table method. The study group received systematic rTMS treatment, and the control group received pseudo-stimulation, for a total of 8 W. Before and after treatment for 4weeks and 8weeks, HAMD, MMSE, and MOCA were used to assess patients mood and cognitive status. RESULTS: Before treatment, there were no significant differences in HAMD, MMSE and MOCA scores between the two groups (P>0.05). After 4 and 8 weeks of treatment, there was no significant difference in HAMD, MMSE, MOCA scores between the control group and baseline scores (P>0.05).The HAMD scores of the study group were lower than before treatment, the scores after 8 weeks were lower than after 4 weeks. The MMSE and MOCA scores of the study group were higher than before treatment (P < 0.05), after 8 weeks ,the MMSE and MOCA scores of the study group were higher than after 4 weeks of treatment (P < 0.05). CONCLUSIONS: rTMS can promote the cognitive function recovery and improve the depression mood in patients with MCI, and the cognitive function recovery after 8 weeks of treatment is better than that after 4 weeks of treatment and high safety.
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| 关键词 |
轻度认知功能障碍；经颅磁刺激；认知功能；心理测量
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| KeyWord |
The effects of repetitive transcranial magnetic stimulation on cognitive function and psychology in patients with mild cognitive Impairment
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| 基金项目 |
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| 页码 |
1136-1138 |
张云*.
重复经颅磁刺激对轻度认知功能障碍患者认知功能和心理状态影响 [J].
国际精神病学杂志.
2021; 48; (6).
1136 - 1138.