Journal of International Psychiatry

[Abstract] Objective: to analyze the efficacy of sodium valproate and lamotrigine in the treatment of epilepsy and its influence on the psychological state of patients. Methods: 112 patients with epilepsy in our hospital from January 2019 to January 2020 were selected and divided into two groups according to "different treatment methods". 56 patients in the reference group were treated with sodium valproate, and 56 patients in the experimental group were treated with sodium valproate + lamotrigine. The clinical efficacy, neurotrophic index, MOCA score, HAMA score, HAMD score and the total incidence of adverse reactions were compared between the two groups. Results: the clinical total effective rate of the experimental group (96.43%) was higher than that of the reference group (75.00%), the serum NGF, BDNF and MOCA scores of the experimental group were higher than those of the reference group after treatment, and the HAMA scores and HAMD scores of the experimental group were lower than those of the reference group after treatment, the differences were statistically significant (P < 0.05). The total incidence of adverse reactions in the experimental group (5.36%) was higher than that in the control group (7.14%), P > 0.05. Conclusion: valproate + lamotrigine can effectively improve the clinical symptoms and neuronutrition of patients with epilepsy, reduce the negative emotions of patients with less adverse reactions.

[Key words] sodium valproate; Lamotrigine; Epilepsy; Clinical effect; mentality